Author

Mengling Chen

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Open access Aug 2026

Original research Bifidobacterium breve LE4 Reduces Alzheimer's Disease Pathology and Confers Neuroprotection by Attenuating Neuroinflammation, Restoring Metabolism, and Preserving Gut Barrier

Emerging evidence implicates gut microbiota dysbiosis in Alzheimer's disease (AD) pathogenesis, suggesting probiotic interventions as a viable therapeutic strategy. This study systematically screened 18 Bifidobacterium strains, among which Bifidobacterium breve LE4 exhibited both potent antioxidant activity and lip...

Liu Yang, Yutian Huang, Meng-Ling Chen et al. · Food Science and Human Welln... · 0 citations

Oct 2026

Akkermansia muciniphila HHAKKα Prevents High-Fat Diet-Induced Obesity in Mice via Gut Microbiota Modulation and Regulation of Hepatic Lipid Metabolism.

Obesity and its associated metabolic disorders pose significant global health challenges. This study investigated the anti-obesity effects of Akkermansia muciniphila HHAKKα in high-fat diet (HFD)-induced obese mice. C57BL/6J mice were administered HHAKKα orally for 8 weeks while maintained on HFD. Results demonstrated...

Gui-Qiu Zhou, Meng-Ling Chen, Ling-Ling Zhao et al. · The FASEB Journal · 0 citations

Aug 2026

Pasteurized Akkermansia muciniphila AKK PROBIO ameliorates inflammation and metabolic disorder in db/db mice with alterations in gut microbiota and hepatic TLR4/NF-κB and SREBP2/HMGCR signaling.

It is indicated that pasteurized AKK PROBIO ameliorates metabolic disorder and inflammation in db/db mice, accompanied by changes in gut microbial ecology, serum metabolites, and hepatic inflammatory/lipid metabolic signaling.

Mengling Chen, Rao Li, Yang Xiang et al. · The Journal of the Science o... · 0 citations