Liquiritigenin attenuates inflammatory periapical bone loss by stabilizing TRIM31 and restraining NLRP3 inflammasome and cGAS-STING inflammatory signaling.
Apical periodontitis (AP) is characterized by persistent inflammation and progressive periapical bone resorption, processes increasingly associated with NLRP3 inflammasome activation and cGAS-STING-related inflammatory signaling. However, pharmacological approaches targeting these inflammatory pathways and their upstre...