Cellular senescence is a stress-responsive state marked by sustained proliferative arrest and changes in metabolism, chromatin organization, secretion, and immune signaling. In ovarian cancer (OC), platinum therapy and PARP inhibition can generate senescence-associated states with distinct consequences. Their effects d...
ABSTRACT Chronic intestinal inflammation is a major driver of colorectal cancer (CRC). As the mucosal barrier's frontline sentinel, the intestinal epithelium initiates the inflammation‐to‐cancer transition. However, the early cell‐intrinsic events that convert inflammatory responses into a sustained pro‐tumorigenic pro...
Yu-Meng Yang, Zhi-Gang Bai, Hai-Bo Wang et al.· Advancement of science· 0 citations
The geroncogenic shift framework provides a conceptual basis for linking aging biology with tumor evolution and for developing more selective approaches to senescence-directed therapy.
Yu-Bo Zhang, Yue Han, Pin-Zhi Hou et al.· Frontiers in Pharmacology· 0 citations
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