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Author

Meng Shen

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Open access Aug 2026

Orthogonal Cas13a/Cas12a cascade for one-pot amplification-free detection of miRNA-21.

This one-pot Cas13a/Cas12a cascade fluorescence biosensor enabled quantitative detection of miRNA-21 over a concentration range of 1-1000 pmol/L within 60 min, with a low detection limit of 0.66 pM.

Jing Yuan, Meng Shen, Li-Hua Ding et al. · 0 citations
Jul 2026

Signal logic gate mediated by a controllable CRISPR/Cas12a system for simultaneous detection of DNA mutation and methylation.

A controllable CRISPR/Cas12a-based signal logic gate that enables simultaneous detection of KRAS G12C mutation and Septin9 promoter methylation in a single reaction and offers a simple and reliable platform for simultaneous genetic and epigenetic analysis in point-of-care cancer screening.

Zonghua Wen, Cong Wei, Meng Shen et al. · 0 citations

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