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Author

Meng Sun

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Open access Aug 2026

PRDM5 regulates ASK1 transcription to affect macrophage inflammation, lipid accumulation and apoptosis progression.

PRDM5 serves as a common susceptibility gene for ASCVD and facilitates macrophage pathogenic phenotypes via the ASK1/JNK/NF-κB cascade, with significantly upregulated expression in monocytes and plaque tissues from patients.

Meng Sun, Han Sun, Hanzheng Wang et al. · 0 citations
Open access Aug 2026

Preliminary functional characterization of the LMNA c.929 A > G (p.Gln310Arg) variant identified in a patient with dilated cardiomyopathy

Preliminary variant-specific functional evidence is provided but do not establish the pathogenicity of the variant or the causal relationships among the observed cellular abnormalities, and further validation in endogenous and physiologically relevant cardac models is required.

Zi-Kang Han, Yong-Hao Sheng, Hanice Sun et al. · 0 citations

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