Gastrodin alleviates mild cognitive impairment and Alzheimer’s disease via candidate targeting of ACHE, S1PR5, SERPINE1, and TOP2A: an integrative computational and cellular study
Alzheimer’s disease (AD) and its prodromal mild cognitive impairment (MCI) lack effective disease-modifying therapeutic strategies. Gastrodin (GAS), the major bioactive compound of Gastrodia elata , exhibits pronounced neuroprotective effects. However, the precise candidate molecular targets and systematic mech...