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HAO2 downregulation is associated with advanced disease, unfavorable survival, and distinct metabolic and immune features in RCC, and represents a candidate tissue-associated biomarker warranting further experimental and prospective validation.
BACKGROUND Acesulfame potassium (ACE) is a widely used low-calorie artificial sweetener that is frequently detected in aquatic environments. Although previous studies have documented metabolic, oxidative, and behavioral effects of ACE, its developmental and neurobehavioral effects during early life stages remain insuff...
Primary tumors show an immunosuppressive phenotype, suggesting potential benefits from combining CTLA4 or IDO1 inhibitors with PD-1 blockade, and Liver metastases exhibit distinct immune features, supporting the need for site-specific precision therapies.
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