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Review Open access Aug 2026

Genome-Wide Prenatal cfDNA Screening and the Obstetric Incidentalome: Maternal Cancer, Placental Mosaicism, and Pregnancy Risk

Abstract Prenatal cell-free DNA (cfDNA) screening was introduced as a highly accurate test for common fetal aneuploidies, but genome-wide implementation has exposed a broader and more complex clinical landscape. Maternal plasma cfDNA is a composite biological signal rather than a fetal signal in isolation. It contains...

Meng Xu, Yuling Liu, Meiling Gao et al. · 0 citations

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