The long-standing challenge of seasonal influenza vaccines providing poor protection is attributed to the rapid and continuous evolution of the virus. In theory, the recommendation of vaccine strain is to predict the dominant strain with best fitness in the upcoming season. Here, we develop FutureFlu, a biologically-gr...
Lu-Yao Qin, Meng-Yi Zhang, Xiao-Yuan Liu et al.· bioRxiv· 0 citations
ABSTRACT Seasonal influenza A/H3N2 poses a significant public health burden due to its rapid antigenic evolution, necessitating frequent vaccine updates. This study systematically analysed the antigenic evolution of 14 H3N2 vaccine strains (2000–2022) using pseudovirus-based neutralization assays and antigenic cartogra...
Yi-Meng An, Mei-Na Cai, Chen-Yan Zhao et al.· Emerging Microbes and Infect...· 0 citations
Recombinant vesicular stomatitis virus (rVSV) is an increasingly popular vaccine vector, but it still faces challenges such as difficulties in construction, low in vitro amplification titers, safety concerns, and uncertain mucosal immune effects. Therefore, there is an urgent need to construct new VSV vectors for next-...
Ziteng Liang, Meng-Yi Zhang, Jie Zhang et al.· Signal Transduction and Targ...· 0 citations
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