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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

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Meng-Yue Xu

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Open access Oct 2026

Integrated Single-Cell Transcriptomics, Multi-Omics, and Mendelian Randomization Reveal Ferroptosis-Related Molecular Subtypes and a Genetically Supported Causal Candidate in Psoriasis

Background Ferroptosis contributes to inflammatory skin diseases, but its role in psoriasis remains incompletely understood. We performed an integrated multi‑omics analysis combining single‑cell transcriptomics, bulk transcriptomics, machine learning, consensus clustering, and Mendelian randomization (MR) to characteri...

Meng-Yue Xu, Yong-Jie Zuo, Hong-Xia Liu et al. · 0 citations
Open access Sep 2026

Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer

This study identifies a novel ‘PD-L1–ER stress–pyruvate–macrophage senescence’ axis as a key mechanism underlying primary resistance to ICB and proposes that targeting the PDK4/GLS-dependent pyruvate surge offers a promising therapeutic strategy to sensitize tumors to anti-PD-1 immunotherapy.

Wen-Xin Lian, Hui Yang, Yu-Qi Zhang et al. · 0 citations

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