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Open access Oct 2026

A circRNA-microRNA-Pdcd1 axis drives microglial activation and retinal ganglion cell degeneration

These findings not only uncover a novel circRNA-mediated mechanism in neurodegeneration but also identify the circAgtpbp1-miR-3098-3p-Pdcd1-microglia axis as a promising therapeutic target for neuroprotective interventions.

Lan-Fang Sun, Xiao-Yu Ke, J.-J. Yu et al. · 0 citations
Open access Aug 2026

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Overall, BraMARS provides a biologically interpretable histopathology‐based framework for estimating subsequent BM risk in resected LS‐SCLC, with potential to support individualized intracranial risk assessment, intensified MRI surveillance, and hypothesis generation for prospective BM‐prevention strategies.

Zi-Jian Yang, Taolue Wang, Shilong Liu et al. · 0 citations

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