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Author

Mengfei Long

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Jul 2026

Rational design of ancestral L-asparaginase via dynamics-guided engineering for improvement of thermostability and acrylamide mitigation efficiency.

L-asparaginase (ASNase) is used both for treating acute lymphoblastic leukemia and as a processing aid to hydrolyze L-asparagine prior to heating, thereby suppressing acrylamide formation in foods and certain traditional Chinese medicinal materials. Industrial pretreatment, however, typically involves high temperature,...

Linyu Luo, Sheng-Yu Zhang, Jingbo Zhou et al. · 0 citations
Aug 2026

Computer-aided multi-shell electrostatic remodeling of BhS7Xyl for enhanced activity and Thermostability.

Xylanases with high catalytic efficiency and environmental robustness are important for lignocellulosic biomass valorization, but many enzymes are rapidly inactivated under the alkaline and high-temperature conditions used in industrial processes. In this study, a computationally guided rational-design strategy was dev...

Chun-Lin Tan, Xin Yu, Lan-Xi Sun et al. · 0 citations

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