The ULK (Unc-51-like kinase) family, a group of serine/threonine protein kinases, plays a central regulatory role in the initiation of autophagy. Autophagy has a dual role in cancer, as it can both inhibit tumor formation and promote the survival and progression of established tumors, making targeting autophagy an attr...
High ULK3 expression and amplification were associated with poor clinical outcomes, tumor stemness, immunosuppression, and RNA dysregulation, and the potential value of ULK3 as a pan-cancer diagnostic and prognostic biomarker and as a predictor of immunotherapy response, particularly in prostate cancer.
Yang-Yang Han, Mengqi Zhang, Mannizire Rehemujiang et al.· International Journal of Mol...· 0 citations
Overall, PRMTs and cancer research represents a promising research direction, and members of the PRMT family have potential utility as cancer biomarkers and therapeutic targets.
Mengjia Li, Lijing Zhan, Jinlin Cui et al.· Medicine· 0 citations
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