Open access
Aug 2026
H3.3 chaperone Hira primes the effector program and function of regulatory T cells
It is shown that the histone variant H3.3 is enriched in tissue Tregs compared to splenic Tregs and its chaperone Hira is a critical regulator of Treg effector program, revealing a previously unreported epigenetic mechanism critical for Treg effector differentiation and function.
Xiang-Xiang Cao, Meng-Jie Lv, Zhi-Han Lv et al.
· Science Advances · 0 citations