Donor-specific antibodies enhance inflammatory immune remodeling associated with TAK1/NF-κB and IL-6/STAT3 signaling in a liver transplantation-related co-culture model.
Antibody-mediated rejection (AMR) after liver transplantation remains underrecognized, and how donor-specific antibodies (DSAs) amplify inflammation within the liver immune microenvironment remains unclear. We generated DSA-positive serum in Lewis rats through Brown Norway splenocyte infusion and skin-allograft presens...