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Author

Meredith Parmer

2 papers indexed here

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Open access Sep 2026

Bile acid sequestration reveals microbiome remodeling that dominates FXR signaling to shape host responses to enteric infection

Approximately 90 million American adults are hypercholesterolemic, with an estimated 43 million individuals either already using or eligible to receive cholesterol-lowering medications, such as bile acid sequestrants. Although bile acid sequestrants have demonstrated therapeutic efficacy in lowering cholesterol levels...

Anahita Mansouripour, D. Seeger, Meredith Parmer et al. · 0 citations
Open access Jul 2026

Adenylosuccinate acts as a novel pro-angiogenic factor

We recently demonstrated a dramatic 77-fold increase in brain adenylosuccinate (AdSucc) concentration during ischemia, reaching ~0.56 mM levels. Previously, the role of AdSucc induction under decreased energy charge was attributed to the activation of purine nucleotide (PNC) and the tricarboxylic acid cycle (TCA). Howe...

Brennon Schofield, D. Seeger, Derek Besch et al. · 0 citations

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