Merle Flecks

Functional Autoantibodies Against G-Protein-Coupled Receptors: Insights into Molecular Mechanisms, Clinical Relevance and Therapeutic Perspectives

G-protein-coupled receptors (GPCRs) represent the largest superfamily of membrane-bound receptors in the human organism and are involved in the regulation of numerous physiological processes in almost all organ systems. Characterized by seven transmembrane domains and coupling to heterotrimeric G-proteins, they mediate...