Polypharmacological neurotoxic effects of methylisothiazolinone revealed by integrated in vitro and network-based chemoinformatics approaches.
Methylisothiazolinone (MIT) is a widely used biocidal preservative in industrial and cosmetic products. However, evidence of its neurotoxic effects is limited, and the mechanistic pathways are poorly defined. This study investigated the neurotoxic potential of MIT and the molecular mechanisms underlying its cellular to...