Targeted protein degradation has transformed drug discovery by replacing occupancy-driven inhibition with event-driven removal of disease-causing proteins, opening previously “undruggable” targets, including transcription factors, scaffolding proteins, and intrinsically disordered regions, to therapeutic intervention....
Walaa S. Aburayan, Ibrahim A. Alradwan, Beshair A. Alsaffar et al.· Pharmaceutics· 0 citations
Overall, site-specific integration provides a framework for linking CAR placement to therapeutic function, but no single locus or integration strategy is universally optimal and clinical evidence remains limited relative to the expanding preclinical landscape.
Hala Aldahshan, Abeer Al-Hubaysh, Dimah K. Alrabiah et al.· Biomedicines· 0 citations
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