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Mi-Na Lee

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Open access Oct 2026

Sinapaldehyde Induces Mitochondrial Dysfunction and Modulates Autophagy/Mitophagy-Associated Signaling and Apoptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC) is highly aggressive and lacks targeted therapies. This study investigated the anti-cancer mechanisms of sinapaldehyde (SNAH). The biological effects of SNAH were evaluated in vitro using MDA-MB-231 TNBC cells. Cellular responses, including autophagy, mitochondrial function, apoptos...

H. Kumarasinghe, Ducdat Le, Ji-Hyang Kim et al. · 0 citations
Open access Oct 2026

Integrated UHPLC-MS/MS Metabolomics, Network Pharmacology, Molecular Docking, and Experimental Validation Reveal the Anti-Inflammatory Mechanisms of Pyrus pyrifolia Peel Extract

These findings provide mechanistic evidence supporting the traditional medicinal use of P. pyrifolia and establish a theoretical framework to develop phytopharmaceuticals for inflammatory diseases.

Ducdat Le, D. Rhyu, Mi-Na Lee · 0 citations
Aug 2026

Characterization of a plasma-derived protein fraction from Magallana gigas and its modulatory effects on lipopolysaccharide-induced inflammatory responses in HT-29 cells.

A plasma-derived protein fraction (MG-1) was partially purified from the hemolymph of the Pacific oyster, Magallana gigas, and its potential modulatory effects on lipopolysaccharide (LPS)-induced inflammatory responses were evaluated in HT-29 intestinal epithelial cells. SDS-PAGE analysis revealed two major protein ban...

Seung-Yub Song, Sung-Ho Lee, Dae-Hun Park et al. · 0 citations
Aug 2026

New glycosides from the leaves of Lansium domesticum: Isolation, structural elucidation, and anti-inflammatory activity.

Integrated network pharmacology and molecular docking analyses suggested that the active glycosides may exert their anti-inflammatory effects through the modulation of multiple inflammation-related targets and signaling pathways, providing a plausible mechanistic basis for their observed anti-inflammatory activity.

H. Q. Nguyen, Hien Thi Tran, L. T. Thao et al. · 0 citations

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