Mianbin Wu

Metabolic Engineering of Yarrowia lipolytica for High-Level de novo Biosynthesis of Xylitol from Glucose.

Xylitol is a highly functional sweetener with extensive applications. Sustainable biosynthesis from glucose is desirable yet metabolically challenging. Here, we engineered Yarrowia lipolytica as a cell factory by constructing a core biosynthetic route via combinatorial screening and multicopy integration of d-arabitol...