Author

Miao He

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Sep 2026

SIK3-mKO Enhances Myelin Debris Phagocytosis via CD11c Complement Pathway for White Matter Protection Poststroke.

BACKGROUND White matter preservation is a rate-limiting factor in neurological recovery after ischemic stroke and depends on efficient clearance of myelin debris by microglia/macrophages. Our prior work demonstrated that microglia/macrophage-specific SIK3 (salt-inducible kinase) knockout (SIK3-mKO) promotes an anti-inf...

Lei-Lei Mao, Chen-Ran Wang, Ke Wang et al. · Stroke · 0 citations

Aug 2026

Prefrontal Neurons Projecting to the Dorsomedial Striatum and Insular Cortex Support Reward Learning.

A subpopulation of mPFC neurons collateralizing to the dorsomedial striatum and the contralateral anterior insular cortex is identified that responded robustly to reward stimuli and exhibited learning-enhanced, unconditioned stimulus (US)-evoked activity during reward conditioning, whereas conditioned stimulus response...

Baihui Ren, Mengmeng Shao, Qingdan Kong et al. · Neuroscience Bulletin · 1 citation

Open access Jul 2026

Delayed astrocyte development impairs Sema6a-Plxna2/4-mediated astrocyte-neuron crosstalk and causes depressive-like behavior

It is demonstrated that Egfr knockout during the critical period of neuronal maturation results in a transient absence of astrocytes, with recovery observed in adult mice, and developmental disruption of EGFR signaling leads to transient astrocyte loss and impaired astrocyte–neuron crosstalk.

Xin Jiang, Yanqing Qi, Lin Yang et al. · Nature Communications · 0 citations