Open access
Aug 2026
The NF-κB/miR-378c/IRG1 axis drives tubular injury in septic AKI by suppressing immunometabolic protection
A maladaptive NF-κB/miR-378c/IRG1 axis in septic AKI is defined, where inflammation-induced miR-378c silences a key metabolic protector in tubular cells and represents a promising therapeutic strategy to preserve renal function during sepsis.
Lulu Zhou, Xiang Zhou, Hong-Mei Deng et al.
· Renal Replacement Therapy · 0 citations