Michael B. Fowler

Gut microbiome shifts in chronic systolic heart failure are associated with disease severity and clinical improvement

The contribution of the gut microbiome to chronic heart failure (HF) remains poorly defined. We performed integrated microbiome and host multi-omic profiling of adults with chronic systolic HF due to nonischemic cardiomyopathy (n = 59) and healthy participants (n = 50), including longitudinal sampling in some cases. He...