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Author

Michael Bader

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Open access Sep 2026

Effects of Constitutive Depletion or Excess of Serotonin during Development on the Maturation of Prefrontal Monoaminergic Circuits

Serotonin (5-hydroxytryptamine; 5-HT) is a critical neuromodulatory morphogen-like signal that governs prenatal cortical circuit assembly, and altered 5-HT signaling is implicated in a wide range of psychiatric disorders. Yet the structural consequences of lifelong 5-HT imbalance during the initial blueprinting phase...

Marta C. F. Samina, Maria Stanciu, Thibault Merkelijn et al. · 0 citations
Open access Sep 2026

Tph2 deficiency shapes neurodevelopmental behavioral trajectories through interactions with the maternal environment, sex, and the gut microbiome

Serotonin (5-HT) is critical for neurodevelopment, influencing brain maturation, emotional regulation, and social behavior. Tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme for central 5-HT synthesis, causes lifelong 5-HT depletion when disrupted. While early-life 5-HT perturbations are linked to neuropsyc...

Marta C. F. Samina, Rogério C. R. Castro, Thijs Lodder et al. · 0 citations

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