Author

Michael G. Poirier

3 papers indexed here

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Open access Aug 2026

Cohesin facilitates nucleosome invasion by transcription factors

Nucleosomes present a major barrier to transcription factor (TF) binding. However, a subgroup of TFs known as pioneer factors (PFs) can recognize motifs covered by nucleosomes and initiate chromatin opening. PFs also bind nucleosomal substrates with high affinity in vitro, which may facilitate their nucleosome invasion...

Shane Stoeber, Hengye Chen, Ruo-Wen Chen et al. · Science Advances · 0 citations

Open access Sep 2026

Fusion Oncoprotein EWSR1::FLI1 Invades Nucleosomes at Consensus ETS Motifs and GGAA Microsatellites

Ewing sarcoma is an aggressive bone malignancy occurring in children, adolescents, and young adults. Most cases are caused by expression of the fusion oncoprotein EWSR1::FLI1, which contains the low complexity domain (LCD) of EWSR1 and the DNA-binding domain (DBD) of FLI1. Previous genomic studies indicate EWSR1::FLI1...

Ruo-Wen Chen, R. Zhou, E. J. Tokarsky et al. · bioRxiv · 0 citations

Open access Jul 2026

Free energy spectroscopy reveals the mechanistic landscape of chromatin compaction

Abstract Eukaryotic genomic DNA is repeatedly wrapped into nucleosome spools: the basic building block of chromatin. This organization regulates the physical accessibility of the genome to gene transcription, replication, and repair regulatory factors. Chromatin compaction is controlled by multivalent weak interactions...

Kalven Bonin, Yuchen Wang, Ivan Riveros et al. · Nucleic Acids Research · 0 citations