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Author

Michael Grabe

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Open access Jun 2026

Hydrophobic mismatch induces lipid sorting based on tail unsaturation

Biological membranes contain a diverse set of membrane proteins surrounded by many different lipids, and the lateral organization and function of these molecules are closely intertwined. Here, we use coarse-grained molecular dynamics (MD) simulations to explore how hydrophobic mismatch between the length of transmembra...

Niek van Hilten, Michael Grabe · 0 citations
Open access Aug 2026

Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution

Inner mitochondrial membrane proteins must be sufficiently hydrophilic to withstand aqueous exposure during translation and transit to the mitochondria. Meanwhile, their transmembrane segments must be sufficiently hydrophobic to stably embed in the lipid membrane. We hypothesized that sequence-level adaptations evolved...

Tarun Yadav, Jonathan Borowsky, Á. Narbona-Pérez et al. · 0 citations

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