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Author

Michael J. Bromley

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2 papers indexed here

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Open access Aug 2026

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

ABSTRACT Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. In this study, we put forward a novel antifungal strategy that targets the conserved global secondary metabolic pathway in pathogenic...

Zili Song, Can Zhao, Qiaoling Wang et al. · 0 citations
Open access Jul 2026

Enzymatic glycosylation and amidation reshapes polyene bioactivity

Pathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentation and potential for safe use as antifungal treatments is described.

Saadia N. Mirza, Alberto Carella, Joseph W. Thompson et al. · 1 citation

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