Author

Michael J. Eck

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Open access Oct 2026

Cryo-EM and biochemical characterization of a BRAF/CRAF heterodimer shows that the NtA motif negative charge is dispensable for RAF activation.

Upon RAS-driven membrane recruitment, RAF kinases ARAF, BRAF, and CRAF are activated through homo- or heterodimerization to initiate MAP kinase signaling. Although RAF heterodimers drive physiologic and oncogenic signaling, they remain little studied structurally and biochemically. Here, we report the preparation, bioc...

Byung Hak Ha, Emre Tkacik, D. Gazgalis et al. · Cell Reports · 1 citation

Review Open access Aug 2026

Towards better outcomes for epidermal growth factor receptor L858R+ lung cancer patients: mutant-selective allosteric inhibitors and the potential for double-drugging.

Next-generation EGFR inhibitors with a particular focus on allosteric inhibitors developed for L858R-mutant NSCLC are surveyed, offering the possibility of double-drugging the mutant receptor to achieve deeper and more durable responses for EGFR L858R+ patients.

Michael J. Eck, David A. Scott · Philosophical transactions o... · 1 citation