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Author

Michael L. Whitfield

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Open access Aug 2026

Abatacept Reduces CD319+ (SLAMF7) Cytotoxic T Cells and Cytokine Production in Systemic Sclerosis.

Abatacept selectively modulates CD319/SLAMF7-expressing cytotoxic T cells and suppresses associated pro-fibrotic and pro-inflammatory cytokines, particularly in the fibroproliferative subtype, where CD319+ T cell reductions correlate with clinical improvement.

Mikel Gurrea-Rubio, Laura A. Cooney, Kohei Maeda et al. · 0 citations
Open access Jul 2026

Treatment Responses Alter Myeloid Activation in BRAF-Mutant Melanoma 2252856

This work establishes for the first time that BRAFi promotes myeloid-mediated induction of T cell activation, which is lost at resistance but can be rescued with the addition of CDDO- me, and provides the foundation for its potential use in combination therapies for melanoma.

Chen-Yu Wang, G. Torres, Helen C. Jarnagin et al. · 0 citations

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