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Author

Michael Maes

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Aug 2026

Psychological stress-associated ceramide and diacylglyceride lipotoxicity as contributors to first-episode depression pathophysiology: A neuroimmune-metabolic-oxidative stress (NIMETOX) perspective.

Early-stage MDD is characterized by lipid dysregulations, which are linked to psychosocial stress exposure, oxidative stress and attenuated reverse cholesterol transport, and may inform the development of future therapeutic strategies.

V. Sirivatanapa, Pannipa Janta, A. Almulla et al. · 0 citations
Review Open access Jul 2026

Unifying the hallmarks of major depression through neuroimmune–metabolic–oxidative (NIMETOX) dysregulation: a mechanistic systems framework

Evidence is presented that peripheral NIMETOX pathways may lead to neuroinflammation, microglial activation, and neuronal damage and that increased lipid load impairs these central pathways, as well as evidence that peripheral NIMETOX pathways may lead to neuroinflammation, microglial activation, and neuronal damage.

Michael Maes, A. Almulla, Drozdstoj Stoyanov et al. · 0 citations

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