Open access
Sep 2026
uORF-mediated translational control of CAK and Cdk activation in response to low nutrients in yeast.
Cyclin-dependent kinases (Cdks) require activating T-loop phosphorylation, a modification considered constitutive. Here, we examine the regulation of the Cdk-activating kinase, Cak1, in budding yeast. We measure Cak1 levels and the activating T169 phosphorylation of Cdc28 (the budding yeast Cdk) in different nutrients....
H. Blank, Eun-Gyu No, Ainsley E. Nelson et al.
· EMBO Reports · 0 citations