Michael R. Armbruster

Collision Induced Unfolding Predicts the Aggregation of Glycoengineered Monoclonal Antibodies

Monoclonal antibody (mAb) therapeutics exhibit substantial structural heterogeneity, requiring analytical methods capable of rapidly assessing critical quality attributes (CQAs) that influence stability and developability. Non-native aggregation is a key CQA, given its propensity to decrease mAb efficacy and increase...