Author

Michael Regnier

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Open access Sep 2026

Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure.

BACKGROUND Nx3 (novex-3) is an exceptionally small isoform of the giant protein titin, whose structural and functional roles within the sarcomere remain poorly understood. METHODS AND RESULTS We used a comprehensive, multimodal approach to define the key properties of Nx3 in healthy and failing hearts, including its...

W. Linke, Lisa Kümper, A. Fomin et al. · Circulation Research · 0 citations

Open access Jul 2026

Contractility Drives Cardiomyocyte Maturation and the Response to Nanopatterns

Calcium-activated contractility is dispensable for sarcomerogenesis but critical for cardiomyocyte maturation, and mass spectrometry datasets cataloging iPSC-CM maturation represent a useful resource for the cardiovascular research community.

Laura A. Sherer, Abigail Nagle, M. Papadaki et al. · Circulation Research · 0 citations