Oct 2026
Inhibition of mitochondrial permeability transition selectively suppresses thrombogenic platelet procoagulant activity.
Platelets support coagulation by externalizing phosphatidylserine (PS), creating a catalytic surface for thrombin generation and fibrin formation. Although platelet PS exposure is required for hemostasis, excessive procoagulant platelet activity drives thrombosis. Sustained calcium influx after strong agonist stimulati...
Yi-Heng Zhang, Jordan Sandler, O. Owegie et al.
· Blood · 0 citations