Background Immune checkpoint inhibitors (ICIs) have transformed the management of advanced non-small cell lung cancer (NSCLC), but their use is associated with potentially serious immune-related cardiotoxicity, often reflected by elevations in N-terminal pro-B-type natriuretic peptide (NT-proBNP). Identifying patients...
Joanna Ziemska-Legięcka, N. Żeber-Lubecka, Magdalena Borucka et al.· Frontiers in Immunology· 0 citations
Findings identify CDK8 as a transcriptional node of LSC-associated programs and provide a mechanistic rationale for combined CDK8-BET inhibition in molecularly defined AML subsets, which will require validation in functional LSC assays and primary specimens.
M. Statkiewicz, I. Rumieńczyk, U. Pakulska et al.· Cells· 0 citations
Evidence indicates that molecularly guided therapy, particularly when integrated with clinicopathological data, can improve survival and expand treatment options beyond empirical chemotherapy.
K. Tałasiewicz, Michał Mikula, Aleksandra Kapała· Critical reviews in oncology...· 0 citations
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