Author

Michel Sadelain

2 papers indexed here

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Aug 2026

CAR T cell-derived TNF is an early determinant of cytokine release syndrome severity.

Cytokine release syndrome (CRS) is a common and potentially severe toxicity of chimeric antigen receptor (CAR) T cell therapy, characterized by activation of the host myeloid compartment and systemic inflammation. Although downstream effectors such as interleukin-6 (IL-6) and IL-1β are well-characterized, the upstream...

P. Lindenbergh, Theodoros Giavridis, Ophélie Vivier et al. · Science immunology · 2 citations

Open access Aug 2026

Control of breast cancer patient-derived xenografts by CD70-targeted HIT-CAR T cells

CAR T cell therapies have shown clinical success in several tumor types, though not in breast cancer, for which advanced stages remain incurable. CD70 is expressed in a broad range of solid tumor types and is emerging as a molecular target for CAR T cells in renal and ovarian malignancies. Here we show that a subset of...

P. Lindenbergh, Vinagolu K. Rajasekhar, I. Linkov et al. · Frontiers in Immunology · 0 citations