Author

Michel W. Jaworek

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Open access Sep 2026

Unveiling the Formation and Stability of the Droplet Phase of the Thyroid Transcription Factor TTF-1HD/dsDNA Complex under Cell-like Crowding Conditions

Liquid−liquid phase separation (LLPS) of protein−nucleic acid systems plays a key role in gene expression and regulation, yet the molecular mechanisms governing transcription factor condensation remain poorly understood. Using complementary biophysical techniques, we investigated the ability of TTF1-Helix III, a pept...

Michel W. Jaworek, M. Campanile, Roland Winter et al. · Biomacromolecules · 0 citations

Open access Oct 2026

Phosphatidic Acid Vesicles Convert the Prion Protein into β-Sheet Fibrils with a Thermostable Structure but Temperature-Sensitive Packing

Biomolecular cofactors, including nucleic acids and lipids, promote conversion of the cellular prion protein (PrPC) into pathogenic assemblies (prion scrapie, PrPSc), yet the mechanistic role of specific membrane lipids in the earliest stages remains unclear. Previous work showed that phosphatidic acid (PA) vesicles in...

Cyntia Alves, Gabriela Assis-de-Lemos, Michel W. Jaworek et al. · International Journal of Mol... · 0 citations