Author

Michèle Studer

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Open access Sep 2026

An NR2F1-dependent retinoic acid network controls retinal specialization in mice and reveals foveal hypoplasia in patients with BBSOAS

An NR2F1-RA/CYP26A1 regulatory axis linking developmental retinal regionalization to human foveal specialization is established and human NR2F1 binds a conserved regulatory region upstream of CYP26A1, supporting its direct role in regulating local RA availability.

P. Piovani, Carole Belliardo, R. Makam et al. · bioRxiv · 0 citations

Open access Aug 2026

Human cortico-vascular assembloids reveal a CELF2-AHNAK-dependent switch from neuronal to endothelial tropism in glioblastoma cells

CO + EO assembloids are established as an original human model of GBM plasticity at the neurovascular interface and identify CELF2 as a master regulator of GSC tropism and AHNAK as a mediator of vascular affinity, revealing a molecular axis that governs GBM invasion and providing potential avenues for future therapeuti...

Michele Bertacchi, A. Ladoux, A. Saliou et al. · Cell Death & Disease · 0 citations