Open access
Sep 2026
Integrated clinicogenomic analysis reveals the evolution and metastatic tropisms of advanced colorectal cancer
SUMMARY We performed an integrated clinical and genomic analysis of over 7,000 consecutively sequenced colorectal cancer (CRC) samples to comprehensively characterize genetic drivers and metastatic tropisms of CRC. We find that genomic evolutionary changes, such as clonal mutations and oncogenic mutant allele imbalance...
Paolo Manca, H. Walch, Jierui Xu et al.
· Cancer Cell · 1 citation