Open access
Aug 2026
Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking
Adolescent stress is a lifelong risk factor for addiction, but the underlying neural circuit changes remain unknown. Here, we show that chronic unpredictable stress in adolescent mice causes a prominent increase in punishment-resistant reward-seeking – behavior tightly linked to the diagnostic criteria for addiction –...
J. Nadel, Evan S. Swanson, Manhua Zhu et al.
· bioRxiv · 0 citations