The approach provides a valuable model for studying human early embryogenesis, particularly the molecular events surrounding ZGA, and is expected that an individual with ~1 year of experience working with human PSC culture would be able to carry out this protocol.
Md. Abdul Mazid, Yun-Pan Li, Min-Die Zhao et al.· Nature Protocols· 0 citations
It is demonstrated that SALL2 knockdown in primed human pluripotent stem cells (hPSCs) triggers a trophectoderm (TE)-like phenotype, characterized by palisade-like morphology and the up-regulation of TE-associated genes.
Yu Qiao, Jian-Fei Xu, Lin Zheng et al.· bioRxiv· 0 citations
The epigenetic mechanisms underlying the transition of healthy type IIb myonuclei into Ampd3+ myonuclei, revealing key chromatin remodeling events that drive this phenotypic shift are delineated, helps understand the epigenetic events underlying mammalian skeletal muscle aging.
J. An, Guang-Shun Lai, Jing Zuo et al.· The FEBS Journal· 0 citations
A residual population of quiescent Phgdhhigh DTCs that survived initial innate immune clearance and became transiently enriched in micrometastases are identified, providing insights into the development of micrometastasis-targeting regimens.
Yun-Fan Sun, Y. Zhong, Shang Liu et al.· Science· 0 citations
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