Systems-Level Mapping of the Tumor Microenvironment Reveals Immune-Mediated Mechanisms and Potential Targets in Platinum-Resistant Ovarian Cancer
Background: Ovarian cancer remains the most lethal gynecologic cancer, with limited improvements in patient survival despite targeted therapies and a high recurrence rate (~80%). Current standard-of-care for frontline treatment involves platinum-based chemotherapy, but the emergence of resistant clones limits long-term...