Adjunctive Oral Treatment Improves Helicobacter pylori Eradication Without Evidence of a Dose-Response Gradient: An Updated Meta-Analysis Challenging the Oral Reservoir Hypothesis
Standard antibiotic regimens for Helicobacter pylori are failing more often as resistance rises, and the oral cavity has long been proposed as an extragastric reservoir that seeds gastric recolonization.If so, treating the mouth should improve gastric eradication, a testable clinical claim rather than a correlation.We...