Aug 2026
Gaudichaudione H induces GSDME-mediated pyroptosis and apoptosis in esophageal squamous cell carcinoma via ROS-dependent YAP degradation.
Findings highlight GH as a promising natural lead compound for ESCC therapy through a ROS-dependent YAP ubiquitination axis involving JNK signaling activation, which regulates the crosstalk between apoptosis and pyroptosis in ESCC.
Ziyi Bao, Guangtao Zhang, Mijia Shao et al.
· Phytomedicine · 0 citations