Review
Open access
Aug 2026
Convergent Mechanistic Pathways Driving the Anaplastic Phenotype in Thyroid Cancer
The principal mechanistic programs that define the ATC phenotype are described: disruption of cell-cycle and apoptotic control through alterations in TP53, CDKN2A/B, and aberrant MAPK activation; metabolic adaptations involving glycolysis, glutaminolysis, and mitochondrial one-carbon metabolism; reprogramming of canoni...
Anthony Centone, N. DeSouza, Nan Yang et al.
· International Journal of Mol... · 0 citations