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Author

Mikel Gurrea-Rubio

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Open access Aug 2026

Anti-CD6 monoclonal antibody UMCD6 induces CD6 internalization, remodels costimulatory receptor availability, and modulates CD4+ T-cell activation

Introduction CD6 is an immunological synapse-associated receptor that integrates adhesive and signaling cues to shape T-cell activation. We previously showed that, in CD6-humanized mice, the anti-human CD6 monoclonal antibody UMCD6 suppresses disease severity and Th1/Th17 responses in models of autoimmunity, but its me...

K. Maeda, Phillip L. Campbell, Qi Wu et al. · 0 citations
Review Open access Aug 2026

Immunotherapy of cancer without induction of autoimmunity – CD6 as a therapeutic target

The CD6 cell surface glycoprotein is expressed by almost all T cells, a small subset of B cells and a substantial proportion of human natural killer (NK) cells. CD6 has multiple ligands and multiple functional epitopes. It is a component of the immunological synapse, and can positively or negatively influence signal tr...

David A. Fox, Mikel Gurrea-Rubio · 0 citations
Open access Aug 2026

Abatacept Reduces CD319+ (SLAMF7) Cytotoxic T Cells and Cytokine Production in Systemic Sclerosis.

Abatacept selectively modulates CD319/SLAMF7-expressing cytotoxic T cells and suppresses associated pro-fibrotic and pro-inflammatory cytokines, particularly in the fibroproliferative subtype, where CD319+ T cell reductions correlate with clinical improvement.

Mikel Gurrea-Rubio, Laura A. Cooney, Kohei Maeda et al. · 0 citations

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