Mikhail Y. Golovko

Bile acid sequestration reveals microbiome remodeling that dominates FXR signaling to shape host responses to enteric infection

Approximately 90 million American adults are hypercholesterolemic, with an estimated 43 million individuals either already using or eligible to receive cholesterol-lowering medications, such as bile acid sequestrants. Although bile acid sequestrants have demonstrated therapeutic efficacy in lowering cholesterol levels...