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Milene Ortiz-Silva

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Open access Sep 2026

The Gp78 ubiquitin E3 ligase drives mitophagy by regulating omegasome formation

Autophagy is initiated at endoplasmic reticulum (ER)-associated omegasomes, yet how the ER contributes to mitochondrial cargo degradation during early autophagosome formation remains unclear. Gp78 is an ER-resident RING E3 ubiquitin ligase involved in ER-associated degradation (ERAD) that also promotes Parkin-independe...

Milene Ortiz-Silva, Bharat Joshi, Jerry Zheng et al. · 0 citations

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