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Author

Milorad Andjelkovic

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Open access Sep 2026

The novel viper FETUA-3 protein evolved a unique mode of inhibiting snake venom metalloproteinases

Molecular innovation and coevolution play major roles in the evolution of biological diversity, yet we have few instances in which we understand the biological and molecular bases of coevolution. Rattlesnakes and other vipers have evolved resistance to their own novel venom metalloproteinase (MP) toxins through the inv...

N. Dowell, Susana Vázquez Torres, Fiona P. Ukken et al. · 0 citations
Open access Sep 2026

Molecular Determinants of Sequence-Dependent N-glycosylation by the Human Oligosaccharyltransferase

Protein N-glycosylation is catalysed by the oligosaccharyltransferase (OST) complex, yet how local sequon composition controls substrate selection by human OST remains poorly understood. Here we combine atomistic molecular dynamics, alchemical free-energy calculations, in cellulo glycosylation assays and human glycopro...

Milorad Andjelkovic, J. F. Belén-Aguilar, Diego Belda et al. · 0 citations

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